Potential Roles of Peripheral Dopamine in Tumor Immunity

Zhang, Xiang; Liu, Qiaofei; Liao, Quan; Zhao, Yupei

doi:10.7150/jca.20850

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2017; 8(15):2966-2973. doi:10.7150/jca.20850 This issue Cite

Review

Potential Roles of Peripheral Dopamine in Tumor Immunity

Xiang Zhang^*, Qiaofei Liu^*, Quan Liao^✉, Yupei Zhao^✉

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
* These authors contributed equally to this work.

Citation:

Zhang X, Liu Q, Liao Q, Zhao Y. Potential Roles of Peripheral Dopamine in Tumor Immunity. J Cancer 2017; 8(15):2966-2973. doi:10.7150/jca.20850. https://www.jcancer.org/v08p2966.htm

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Abstract

Recent years, immunotherapy has turned out to be a promising strategy against tumors. Peripheral dopamine (DA) has important roles in immune system among tumor patients. Accumulated reports demonstrate variable expression and distribution of DA receptors (DRs) in diverse immune cells. Interestingly, peripheral DA also involves in tumor progression and it exerts anticancer effects on immunomodulation, which includes inflammasomes in cancer, function of immune effector cells, such as T lymphocytes, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and natural killer (NK) cells. Given the specific immunologic status, DA medication may be a valuable candidate in pancreatic cancer treatment. The major purpose of this review is to discuss the novel potential interactions between peripheral dopamine and tumor immunity.

Keywords: Dopamine, Immunomodulation, Cancer, Immunotherapy.

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APA

Zhang, X., Liu, Q., Liao, Q., Zhao, Y. (2017). Potential Roles of Peripheral Dopamine in Tumor Immunity. Journal of Cancer, 8(15), 2966-2973. https://doi.org/10.7150/jca.20850.

ACS

Zhang, X.; Liu, Q.; Liao, Q.; Zhao, Y. Potential Roles of Peripheral Dopamine in Tumor Immunity. J. Cancer 2017, 8 (15), 2966-2973. DOI: 10.7150/jca.20850.

NLM

Zhang X, Liu Q, Liao Q, Zhao Y. Potential Roles of Peripheral Dopamine in Tumor Immunity. J Cancer 2017; 8(15):2966-2973. doi:10.7150/jca.20850. https://www.jcancer.org/v08p2966.htm

CSE

Zhang X, Liu Q, Liao Q, Zhao Y. 2017. Potential Roles of Peripheral Dopamine in Tumor Immunity. J Cancer. 8(15):2966-2973.

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