J Cancer 2017; 8(12):2296-2302. doi:10.7150/jca.18853

Research Paper

Alcohol Consumption and Lung Cancer According to Ile349Val Polymorphism in ADH3 Gene: Beyond the Tobacco Smoking Effect

Ana Fernández-Somoano1,2✉#, Sara M Álvarez-Avellón1,2#, Ana Souto-García1,2, Jesús Vioque1,3, Eva M Navarrete-Muñoz1,3, Adonina Tardón1,2

1. Molecular Epidemiology of Cancer Unit, IUOPA, Universidad de Oviedo. Departamento de Medicina. Oviedo, Asturias, Spain, 33006
2. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III. Madrid, Spain, 28029
3. Public Health Department, Miguel Hernández University, Campus San Juan de Alicante. Sant Joan d'Alacant (Alicante), Spain, 03550
# These authors contributed equally to this work.

Abstract

Objectives: Smoking is the leading cause of lung cancer. However, several studies have suggested other factors such as alcohol consumption could also play a role through polymorphisms associated with alcohol metabolism. We investigated the association between alcohol consumption and lung cancer according to the Ile349Val polymorphism in the alcohol dehydrogenase 3 ADH3 gene.

Methods: We carried out a hospital-based case-control study, a total of 402 incident cases of lung cancer and 383 controls were genotyped for the Ile349Val polymorphism by polymerase chain reaction combined with restriction fragment length polymorphism. Alcohol consumption and other variables were measured using questionnaires in personal interviews. We used multiple logistic regressions to estimate adjusted odd ratios using and 95% confidence intervals.

Results: In multivariate analysis, an increased risk of lung cancer was observed for the highest category of alcohol consumption (≥30 g/day), although it does not reach statistical significance (OR=1.60, 95% CI: 0.91-2.83). Besides, an increased risk of lung cancer was observed in the highest category of alcohol consumption for the Ile/Val genotype compared with the Ile/Ile genotype (OR=2.35, 95% CI: 1.04-5.33).

Conclusions: This study suggests that beyond smoking consumption, a high consumption of alcohol might increase the risk of lung cancer. No clear association was found between alcohol consumption and lung cancer according to the Ile349Val polymorphism in ADH3 gene.

Keywords: Alcohol, Lung Cancer, Polymorphism, Acetaldehyde

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How to cite this article:
Fernández-Somoano A, Álvarez-Avellón SM, Souto-García A, Vioque J, Navarrete-Muñoz EM, Tardón A. Alcohol Consumption and Lung Cancer According to Ile349Val Polymorphism in ADH3 Gene: Beyond the Tobacco Smoking Effect. J Cancer 2017; 8(12):2296-2302. doi:10.7150/jca.18853. Available from http://www.jcancer.org/v08p2296.htm