MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma

Liang, Wei; Wei, Xi; Li, Qing; Dai, Nan; Li, Chong-Yi; Deng, Yi; Jiang, Xuan; Tan, Xiao-Rong; Dai, Xiao-Yan; Li, Meng-Xia; Xu, Cheng-Xiong; Wang, Dong; Zhong, Zhao-Yang

doi:10.7150/jca.18680



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2017; 8(9):1542-1551. doi:10.7150/jca.18680 This issue Cite

Research Paper

MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma

Wei Liang^1*, Xi Wei^2*, Qing Li¹, Nan Dai¹, Chong-Yi Li¹, Yi Deng, Xuan Jiang¹, Xiao-Rong Tan¹, Xiao-Yan Dai¹, Meng-Xia Li¹, Cheng-Xiong Xu¹, Dong Wang¹, Zhao-Yang Zhong^{1 ✉}

1. Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing,400042, China;
2. Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China.
* These authors Wei Liang and Xi Wei contributed equally to this work.

Citation:

Liang W, Wei X, Li Q, Dai N, Li CY, Deng Y, Jiang X, Tan XR, Dai XY, Li MX, Xu CX, Wang D, Zhong ZY. MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma. J Cancer 2017; 8(9):1542-1551. doi:10.7150/jca.18680. https://www.jcancer.org/v08p1542.htm

Other styles

Abstract

Human osteosarcoma (HOS) is the most common malignancy in children and adolescents and has a heterogeneous presentation and high mortality. Previous studies have shown that microRNAs contribute to RNA silencing and post-transcriptional regulation of gene expression. Here, we showed that significantly increased expression of miR-765 with or without CDDP (Cisplatin) down-regulates APE1 expression and angiogenesis-related markers (VEGF, FGF2, TGFβ, and CD34). Further investigation showed that miR-765 modulates osteosarcoma cell migration and angiogenesis following treatment with cisplatin in vitro and in vivo. MiR-765 increases the anti-angiogenic effect of CDDP in human osteosarcoma. Elucidation of the mechanism of the miR-765-APE1 axis in tumor progression of HOS will be beneficial in identifying biomarkers and therapeutic target of osteosarcoma.

Keywords: MicroRNA-765, APE1, Cisplatin, Anti-angiogenesis, Osteosarcoma.

Citation styles

APA

Liang, W., Wei, X., Li, Q., Dai, N., Li, C.Y., Deng, Y., Jiang, X., Tan, X.R., Dai, X.Y., Li, M.X., Xu, C.X., Wang, D., Zhong, Z.Y. (2017). MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma. Journal of Cancer, 8(9), 1542-1551. https://doi.org/10.7150/jca.18680.

ACS

Liang, W.; Wei, X.; Li, Q.; Dai, N.; Li, C.Y.; Deng, Y.; Jiang, X.; Tan, X.R.; Dai, X.Y.; Li, M.X.; Xu, C.X.; Wang, D.; Zhong, Z.Y. MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma. J. Cancer 2017, 8 (9), 1542-1551. DOI: 10.7150/jca.18680.

NLM

CSE

Liang W, Wei X, Li Q, Dai N, Li CY, Deng Y, Jiang X, Tan XR, Dai XY, Li MX, Xu CX, Wang D, Zhong ZY. 2017. MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma. J Cancer. 8(9):1542-1551.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.