J Cancer 2016; 7(14):2077-2084. doi:10.7150/jca.15797

Research Paper

Prognostic impact of hormone receptor- and HER2-defined subtypes in inflammatory breast cancer treated with high-dose chemotherapy: a retrospective study

Laurys Boudin1,2*, Anthony Gonçalves1, 3, 4✉*, Patrick Sfumato5, Renaud Sabatier1, 3, 4, François Bertucci1, 3, 4, Carole Tarpin1, Magali Provansal1, Gilles Houvenaeghel3, 4, 6, Eric Lambaudie3, 4, 6, Agnes Tallet7, Michel Resbeut7, Emmanuelle Charafe-Jauffret3, 4, 8, Boris Calmels2, 9, 10, Claude Lemarie9,10, Jean-Marie Boher5, Jean-Marc Extra1, Patrice Viens1, 3, 4, Christian Chabannon4, 9, 10

1. Département d'Oncologie médicale, Institut Paoli-Calmettes (IPC), Marseille, F-13273, France.
2. Département d'Oncologie médicale, Hôpital d'Instruction des Armées Sainte Anne, Toulon, 83000, France.
3. Centre de Recherches en Cancérologie de Marseille (CRCM), UMR Inserm 1068 / CNRS 7258 / AMU 105 / IPC, Marseille, F-13009, France.
4. Aix-Marseille Université, Marseille, F-13284, France.
5. Biostatistiques, Département de la Recherche Clinique et de l'Innovation (DRCI), Institut Paoli-Calmettes, Marseille, F-13273, France.
6. Département de Chirurgie Oncologique, Institut Paoli-Calmettes, Marseille, F -13273, France.
7. Département de Radiothérapie, Institut Paoli-Calmettes, Marseille, F-13273, France.
8. Biopathologie, Département de Biologie du Cancer Institut Paoli-Calmettes, Marseille, F-13273, France.
9. Centre de Thérapie Cellulaire, Département de Biologie du Cancer, Institut Paoli-Calmettes, Marseille, F-13273, France.
10. Centre d'Investigations Cliniques en Biothérapies, Inserm CBT-1409, Marseille, F-13009, France.
*both authors equally contribute.

Abstract

Purpose: Studies examining high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDC-AHSCT) strategies in inflammatory breast cancer (IBC), showed encouraging results in terms of disease-free survival (DFS), and overall survival (OS). The lack of data regarding HER2 status in all of these studies prevented any prognostic analysis involving breast cancer subtypes.

Methods: All consecutive female patients treated for IBC with HDC and AHSCT at Institut Paoli-Calmettes between 2003 and 2012 were included. Since 2005, trastuzumab was included in initial treatment. Patient, tumor and treatment characteristics were collected. Patients were categorized in three subtypes based on hormonal receptor (HR) and HER2 status of the primary tumor: Luminal, (HR+/HER2-), HER2 (HER2+, any HR), and triple negative (TN) (HER2- and HR-). The main objective was the analysis of OS according to the IHC subtypes.

Results: Sixty-seven patients were included. Eleven patients received trastuzumab. Median follow up was 80.04 months (95% CI 73.2-88.08). Five-year OS and DFS for the whole population patients were 74% (95% CI 61-83) and 65 % (95% CI 52-75), respectively. OS differed across subtypes (p=0.057) : HER2 subgroup appeared to have the best prognosis with a 5-year OS of 89% (95% CI 64-97) compared to 57% (95% CI 33-76) for the TN subgroup (HR 5.38, 95% CI 1.14-25.44; p=0.034).

Conclusions: In IBC patients receiving HDC-AHSCT, OS favorably compares with data available in the literature on similar groups of patients. TN patients carried the least favourable OS and HER2 patients, half of them also receiving trastuzumab, had the best outcome. These findings provide additional information and options for patients with IBC and who could potentially benefit of HDC-AHSCT.

Keywords: Inflammatory breast cancer, High dose chemotherapy, Immunohistochemical subtypes, Autologous hematopoietic stem cell transplantation.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Boudin L, Gonçalves A, Sfumato P, Sabatier R, Bertucci F, Tarpin C, Provansal M, Houvenaeghel G, Lambaudie E, Tallet A, Resbeut M, Charafe-Jauffret E, Calmels B, Lemarie C, Boher JM, Extra JM, Viens P, Chabannon C. Prognostic impact of hormone receptor- and HER2-defined subtypes in inflammatory breast cancer treated with high-dose chemotherapy: a retrospective study. J Cancer 2016; 7(14):2077-2084. doi:10.7150/jca.15797. Available from http://www.jcancer.org/v07p2077.htm