J Cancer 2016; 7(14):2061-2066. doi:10.7150/jca.16110

Research Paper

The Impact of Diabetes on the Risk of Prostate Cancer Development according to Body Mass Index: A 10-year Nationwide Cohort Study

Jin Bong Choi1,3, Hyong Woo Moon1, Young Hyun Park1,3, Woong Jin Bae1, Hyuk Jin Cho1, Sung-Hoo Hong1,3, Ji Youl Lee1,3, Sae Woong Kim1, Kyung-Do Han2, U-Syn Ha1,3✉

1. Department of Urology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
2. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
3. The Cancer Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.

Abstract

Purpose: We examined the association between obesity and prostate cancer both with and without diabetic patients included in the analysis using nationally representative data of the Korean population from the National Health Insurance System (NHIS).

Materials and Methods: Of the 424,712 participants who underwent health examinations in 2002-2008, 139,519 men ≥40 years old and without prostate cancer were followed from the beginning of 2002 to the end of 2012. Multivariate adjusted Cox regression analysis was conducted to examine the hazard ratio (HR) and 95% confidence interval (CI) for the association between prostate cancer and body mass index (BMI) both with and without diabetes.

Results: The HR for prostate cancer according to the existence of diabetes was stratified by BMI in both age- and multivariable-adjusted models. In the population without diabetes, the HR for prostate cancer significantly increased as BMI increased beyond the reference range in a model adjusted for age and multiple variables; however, the increase in the HR was small. In the population with diabetes, the HR for prostate cancer significantly increased as BMI increased from < 18.5 kg/m2 to within the reference range (18.5 to 22.9) in the multivariable-adjusted model. In addition, a marked decrease in HR in the population with BMI of < 18.5 kg/m2 was seen compared to the reference or higher BMI population.

Conclusion: This population-based study shows the evidence of association between obesity and development of prostate cancer, and the risk increases vary according to the change of BMI category and the existence of diabetes.

Keywords: Prostate cancer, Obesity, Diabetes.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Choi JB, Moon HW, Park YH, Bae WJ, Cho HJ, Hong SH, Lee JY, Kim SW, Han KD, Ha US. The Impact of Diabetes on the Risk of Prostate Cancer Development according to Body Mass Index: A 10-year Nationwide Cohort Study. J Cancer 2016; 7(14):2061-2066. doi:10.7150/jca.16110. Available from http://www.jcancer.org/v07p2061.htm