J Cancer 2016; 7(10):1328-1339. doi:10.7150/jca.15419

Review

Pancreatic Cancer from Molecular Pathways to Treatment Opinion

Michail Karanikas1✉, Agis Esempidis1, Zeinep Tzoutze Memet Chasan1, Theodora Deftereou1, Maria Antonopoulou1, Ferdi Bozali1, Kyriakos Amarantidis2, Yan-Gao Man3

1. 1ST Department of Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, Alexandroupolis, 68100 Thrace, Greece.
2. Department of Medical Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, Alexandroupolis, 68100 Thrace, Greece.
3. Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA.

Abstract

Pancreatic cancer is considered one of the most lethal malignances. It has been observed that the five year survival rate is less than 5%. Early diagnosis, understanding the risk factors and investigation of the molecular pathways with targeted therapy are the keys for efficient treatment. Moreover; there are several local treatments for patients with unresectable pancreatic cancer. There are several combined therapies with chemotherapy and radiotherapy, however; a local therapy approach for many patients with poor performance status are in need. For those patients with good performance status new polychemotherapy regimens are used with success and increased survival improvement. Polychemotherapy has been observed to increase the rate of radical resections in some cases. Second line therapy is used for patients with good performance status and metastatic disease. Oxaliplatin-based regimens are mostly used, however; there are several other drugs that are being developed. Unfortunately, targeted therapy has not presented the expected efficiency. Moreover; immunotherapy; another treatment approach for several cancers types has again failed to present positive results for pancreatic cancer. In the current mini review, we will present information from the diagnosis to molecular pathways and targeted treatment.

Keywords: Chemotherapy, Irreversible electroporation, Pancreatic cancer, Radio-frequency, Stereotactic radiotherapy.

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How to cite this article:
Karanikas M, Esempidis A, Chasan ZTM, Deftereou T, Antonopoulou M, Bozali F, Amarantidis K, Man YG. Pancreatic Cancer from Molecular Pathways to Treatment Opinion. J Cancer 2016; 7(10):1328-1339. doi:10.7150/jca.15419. Available from http://www.jcancer.org/v07p1328.htm