ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2016; 7(10):1233-1241. doi:10.7150/jca.14616 This issue Cite
Review
The Role of Mir-148a in Cancer
1. Department of Pathology and Pathophysiology, Hunan Normal University Medical School, Changsha 410013, Hunan, China;
2. Department of Statistics and Epidemiology, Public Health School, Central South University, Changsha 410078, Hunan, China.
Abstract
MicroRNAs (miRNAs) are highly conserved noncoding RNAs of about 19-25 nucleotides. Through specifically pairing with complementary sites in 3' untranslated regions (UTRs) of target mRNAs, they mediate post-transcriptional silencing. MicroRNAs have been implicated in many physiological processes including proliferation, differentiation, development, apoptosis, and metabolism. In recent years many studies have revealed that the aberrant expression of miRNA is closely related to oncogenesis and is now an intense field of study. Mir-148a is aberrantly expressed in various cancers and has been identified as an oncogenic or tumor suppressor with crucial roles in the molecular mechanisms of oncogenesis. In this review, we have summarized the role of mir-148a in the oncogenic pathways of gastric, liver, breast and urogenital cancers, and in neurogliocytoma oncogenesis. Studying the functional role of mir-148a is crucial in discovering novel tumor molecular markers and identifying potential therapeutic targets.
Keywords: miRNA, mir-148a, cancer, oncogene, tumor suppressor gene, biological function.
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