J Cancer 2016; 7(9):1049-1056. doi:10.7150/jca.14778

Research Paper

Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer

Yu-Qin Sun1#, Jian-Wei Xie2#, Peng-Chen Chen3, Chao-Hui Zheng2, Ping Li2, Jia-Bin Wang2, Jian-Xian Lin2, Jun Lu2, Qi-Yue Chen2, Long-Long Cao2, Mi Lin2, Ru-Hong Tu2, Yao Lin3✉, Chang-Ming Huang2✉

1. Department of Gastric Surgery, Fujian Medical University Union Hospital, No.29 Xinquan Road, Fuzhou 350001, Fujian Province, People's Republic of China; College of Life Sciences, Fujian Normal University, Qishan Campus, Fuzhou 350108, Fujian Province, People's Republic of China.
2. Department of Gastric Surgery, Fujian Medical University Union Hospital, No.29 Xinquan Road, Fuzhou 350001, Fujian Province, People's Republic of China;
3. College of Life Sciences, Fujian Normal University, Qishan Campus, Fuzhou 350108, Fujian Province, People's Republic of China.
# These authors contributed equally to this article.

Abstract

Several previous studies have demonstrated that CDK5 or p27 expression in gastric cancer are associated with overall survival. We have previously reported that tumor suppressive function of CDK5 is related to p27. The aim of this study was to investigate correlation between the clinicopathological parameters and overall survival with different CDK5/p27 expression statuses in 244 gastric cancer patients using immunohistochemistry. Low CDK5 expression was detected in 93 cases (38.11%) and low p27 in 157 cases (64.34%). The expression of CDK5 was significantly related to sex (P = 0.034) and Lauren's classification (P = 0.013). The expression of p27 was significantly related to sex (P = 0.012), differentiation (P = 0.003), TNM stage (P = 0.013) and lymph node metastasis (P = 0.001). Based on the combined expression of CDK5 and p27, we classified the patients into four subtypes: CDK5 Low/p27 Low (n = 69), CDK5 High/p27 Low (n = 88), CDK5 Low/p27 High (n = 24) and CDK5 High/p27 High (n = 63). The CDK5 Low/p27 Low expression was closely related to female (P = 0.026), diffuse type (P = 0.027) and lymph node metastasis (P = 0.010). The CDK5 Low/p27 Low patients displayed poorer survival in comparison with the rest of the patients in Kaplan-Meier analysis. No significant overall survival difference was observed among the patients with CDK5 High and/or p27 High expression. In the multivariate analysis, CDK5 and p27 co-expression status was identified as an independent prognostic factor for patients with gastric cancer.

Keywords: Gastric Cancer, CDK5, p27, Prognosis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Sun YQ, Xie JW, Chen PC, Zheng CH, Li P, Wang JB, Lin JX, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Lin Y, Huang CM. Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer. J Cancer 2016; 7(9):1049-1056. doi:10.7150/jca.14778. Available from http://www.jcancer.org/v07p1049.htm