J Cancer 2016; 7(5):595-599. doi:10.7150/jca.13759

Research Paper

The Evaluation of Liver Function and Surgical Influence by ICGR15 after Chemotherapy for Colorectal Liver Metastases

Kiyokazu Hiwatashi1, Shinichi Ueno2✉, Masahiko Sakoda1, Satoshi Iino1, Koji Minami1, Shinichiro Mori1, Yoshiaki Kita1, Kenji Baba1, Hiroshi Kurahara1, Yuko Mataki1, Kosei Maemura1, Hiroyuki Shinchi3, Shoji Natsugoe1

1. Department of Digestive Surgery, Breast and Thyroid Surgery Graduate School of Medical and Dental Sciences Kagoshima University, Sakuragaoka 8-35-1 Kagoshima, 890-8520, Japan.
2. Department of Clinical Oncology, Graduate School of Medical and Dental Sciences Kagoshima University.
3. Faculty of Medical School of Health Sciences, Graduate School of Health Sciences Kagoshima University.

Abstract

Background; Approximately 60% of patients with colorectal cancer develop liver metastasis at some point after diagnosis. The aim of this study is to investigate whether the evaluation of ICGR15 preoperatively is a useful clinical indicator of hepatic injury following chemotherapy and to investigate the influence of multiple chemotherapies on liver function.

Results; Mean ICGR15 values were higher in patients ≥65 years (P = 0.047) and in patients with ≥3 cycles (P = 0.022) and ≥6 cycles (P = 0.001) of systemic chemotherapy. ICGR15 values tended to be higher in patients with postoperative complications (P = 0.085). Patients receiving systemic chemotherapy for ≥6 cycles had higher levels of AST (P = 0.003), ALT (P = 0.015), and alkaline phosphatase (ALP) (P = 0.041). Patients receiving systemic chemotherapy for ≥3 cycles had higher levels of AST (P = 0.015) and ALP (P = 0.015).

Conclusions; Because the pathological diagnosis is usually established only after operation, preoperative evaluation such as the identification of sinusoidal injury is difficult. Based on this study, higher ICGR15 values may provide an indication of surgical complications and be a predictor of liver dysfunction following frequent cycles of chemotherapy. Hepatectomy should be performed with the utmost care in such patients, and the number of cycles of preoperative chemotherapy should probably be as low as possible.

Keywords: ICG, CRLM, chemotherapy.

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How to cite this article:
Hiwatashi K, Ueno S, Sakoda M, Iino S, Minami K, Mori S, Kita Y, Baba K, Kurahara H, Mataki Y, Maemura K, Shinchi H, Natsugoe S. The Evaluation of Liver Function and Surgical Influence by ICGR15 after Chemotherapy for Colorectal Liver Metastases. J Cancer 2016; 7(5):595-599. doi:10.7150/jca.13759. Available from http://www.jcancer.org/v07p0595.htm