J Cancer 2016; 7(3):225-231. doi:10.7150/jca.13906


Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy

Yi-Hsuan Hsiao1,2✉, Shou-Jen Kuo3, Horng-Der Tsai2, Ming-Chih Chou1, Guang-Perng Yeh1,2✉

1. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
3. Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan


The treatment of cancer is an important issue in both developing and developed countries. Clinical use of ultrasound in cancer is not only for the diagnosis but also for the treatment. Focused ultrasound surgery (FUS) is a noninvasive technique. By using the combination of high-intensity focused ultrasound (HIFU) and imaging method, FUS has the potential to ablate tumor lesions precisely. The main mechanisms of HIFU ablation involve mechanical and thermal effects. Recent advances in HIFU have increased its popularity. Some promising results were achieved in managing various malignancies, including pancreas, prostate, liver, kidney, breast and bone. Other applications include brain tumor ablation and disruption of the blood-brain barrier. We aim at briefly outlining the clinical utility of FUS as a noninvasive technique for a variety of types of cancer treatment.

Keywords: focused ultrasound surgery, cancer therapy, high-intensity focused ultrasound, ablation

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How to cite this article:
Hsiao YH, Kuo SJ, Tsai HD, Chou MC, Yeh GP. Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy. J Cancer 2016; 7(3):225-231. doi:10.7150/jca.13906. Available from http://www.jcancer.org/v07p0225.htm