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J Cancer 2015; 6(4):382-386. doi:10.7150/jca.11187 This issue Cite

Short Research Communication

The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma

Yuan-Yuan Li, Sze-Kwan Lam, Chun-Yan Zheng, James Chung-Man Ho✉

Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR

✉ Corresponding author: Dr. James C. Ho M.D. FRCP, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. Tel: (852) 2255 4999; Fax: (852) 2872 5828; Email: jhocmhk

Citation:
Li YY, Lam SK, Zheng CY, Ho JCM. The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma. J Cancer 2015; 6(4):382-386. doi:10.7150/jca.11187. https://www.jcancer.org/v06p0382.htm
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Abstract

Lung cancer is the top cancer killer worldwide. Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC). Autophagy is a cellular response to stress, serving as a protective mechanism during anticancer therapy. The tumor microenvironment (TME) is composed of non-tumor cells that include fibroblasts. Our study aimed to investigate the effect of TME on autophagy and TKI sensitivity. Following cell sorting after direct co-culturing, autophagy and cytokine production were observed in both HCC827 and MRC-5 cells. The synergistic combination of erlotinib and chloroquine (autophagy inhibitor) was observed under TME. Tumor growth was significantly suppressed with combined erlotinib/chloroquine compared with erlotinib in HCC827 xenografts.

Keywords: Tumor microenvironment, autophagy, tyrosine kinase inhibitors, non-small cell lung carcinoma

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APA
Li, Y.Y., Lam, S.K., Zheng, C.Y., Ho, J.C.M. (2015). The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma. Journal of Cancer, 6(4), 382-386. https://doi.org/10.7150/jca.11187.

ACS
Li, Y.Y.; Lam, S.K.; Zheng, C.Y.; Ho, J.C.M. The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma. J. Cancer 2015, 6 (4), 382-386. DOI: 10.7150/jca.11187.

NLM
Li YY, Lam SK, Zheng CY, Ho JCM. The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma. J Cancer 2015; 6(4):382-386. doi:10.7150/jca.11187. https://www.jcancer.org/v06p0382.htm

CSE
Li YY, Lam SK, Zheng CY, Ho JCM. 2015. The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma. J Cancer. 6(4):382-386.

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