J Cancer 2015; 6(1):82-89. doi:10.7150/jca.10679

Research Paper

Changes in Bone Density after Cancer Treatment in Patients with Cervical and Endometrial Cancer

Young Lim Oh1, Man Soo Yoon2, Dong Soo Suh2, Ari Kim3, Min Joung Kim4, Ji Young Lee5, Yong Jung Song6, Yong Il Ji7, Ki Hyung Kim2*✉, Sungwook Chun7*✉

1. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea;
2. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea;
3. Department of Obstetrics and Gynecology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea;
4. Department of Obstetrics and Gynecology, Catholic University School of Medicine, Seoul, Republic of Korea;
5. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea;
6. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Republic of Korea;
7. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Republic of Korea.
* Ki Hyung Kim and Sungwook Chun equally contributed to this article for correspondence.

Abstract

OBJECTIVE: This study aimed to evaluate the impact of cancer treatment on bone mineral density (BMD) in the lumbar spine (LS) and femur in the postmenopausal women with cervical or endometrial cancer without bone metastasis compared to normal control postmenopausal women.

METHODS: We retrospectively evaluated the BMD data in the LS, femur neck (FN) and trochanter (FT) by dual-energy X-ray absorptiometry and laboratory data of bone turnover markers at baseline and after one year in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls.

RESULTS: There were no significant differences in the T-scores of basal BMD in LS and femur between patients with endometrial cancer and controls, and only T-score of basal BMD at the fourth lumbar vertebra (L4) was significantly lower in patients with cervical cancer compared to controls. One year later, T-scores of BMD at all LS sites and FN in patients with cervical cancer and T-scores of BMD at L3, L4, FN, and FT in those with endometrial cancer after cancer treatment were significantly lower compared to controls. Lower proportions of normal BMD at all skeletal sites except L2 in patients with endometrial cancer and those at L1, L4, and FN in patients with cervical cancer were observed compared to controls after cancer treatment.

CONCLUSIONS: Our results suggest that cancer treatment increase bone loss in postmenopausal women with cervical and endometrial cancer.

Keywords: Bone mineral density, Cervical cancer, Endometrial cancer, Osteoporosis.

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How to cite this article:
Oh YL, Yoon MS, Suh DS, Kim A, Kim MJ, Lee JY, Song YJ, Ji YI, Kim KH, Chun S. Changes in Bone Density after Cancer Treatment in Patients with Cervical and Endometrial Cancer. J Cancer 2015; 6(1):82-89. doi:10.7150/jca.10679. Available from http://www.jcancer.org/v06p0082.htm