J Cancer 2014; 5(8):625-627. doi:10.7150/jca.9730

Short Communication

Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer

John Organtzis1, Sofia Lampaki1, Paul Zarogoulidis1✉, Haidong Huang2, Qiang Li2, Antonis Papaiwannou1, Konstantinos Syrigos3, Konstantinos Porpodis1, Theodora Tsiouda4, Wolfgang Hohenforst-Schmidt5, Georgia Trakada6, Robert Fred Henry Walter7,8, Dimitra Makrantonaki9, Georgia Pitsiou1, Ioannis Kioumis1, Konstantinos Zarogoulidis1

1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
2. Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China
3. Oncology Department, ``Sotiria`` Hospital of Chest Diseases, University of Athens, Athens, Greece
4. Internal Medicine Department, ``Thegeneio`` Cancer Hospital, Thessaloniki, Greece
5. II Medical Department, ``Coburg`` Regional Clinic, University of Wuerzburg, Coburg, Germany
6. Department of Clinical Therapeutics, Division of Pneumonology, Medical School, National University of Athens, Athens, Greece
7. Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
8. Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
9. Internal Medicine Department, ``Theagenio`` Anti-Cancer Hospital, Thessaloniki, Greece.


A new drug for chronic obstructive pulmonary disease has been recently added as a treatment for certain patients. However, new evidences indicate that there might be a connection with lung cancer. It is known that smoking is a major factor that induces chronic pulmonary disease and smoking is associated with lung cancer. The level of connection between phosphodiesterase (PDE)-4 inhibitors and lung cancer will be discussed based on current studies. A comment will be made whether lung cancer is induced to patients receiving phosphodiesterase (PDE)-4 inhibitors from the drug or former smoking habit.

Keywords: COPD, phosphodiesterase, inflammation, cancer.

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How to cite this article:
Organtzis J, Lampaki S, Zarogoulidis P, Huang H, Li Q, Papaiwannou A, Syrigos K, Porpodis K, Tsiouda T, Hohenforst-Schmidt W, Trakada G, Walter RFH, Makrantonaki D, Pitsiou G, Kioumis I, Zarogoulidis K. Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer. J Cancer 2014; 5(8):625-627. doi:10.7150/jca.9730. Available from http://www.jcancer.org/v05p0625.htm