J Cancer 2014; 5(2):143-150. doi:10.7150/jca.7439

Research Paper

Evaluation of Antioxidant and Antiangiogenic Properties of Caesalpinia Echinata Extracts

Elisangela Christhianne Barbosa da Silva Gomes1, George Chaves Jimenez2, Luis Claudio Nascimento da Silva3, Fabrício Bezerra de Sá4, Karen Pena Cavalcanti de Souza5, Gerson S. Paiva6✉, Ivone Antônia de Souza7

1. Departamento de Farmácia, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
2. Departamento de morfologia e fisiologia animal, Universidade Federal Rural de Pernambuco. Rua Dom Manoel de Medeiros, S/N, Dois Irmãos, Recife, PE, 52171-900 Pernambuco, Brasil.
3. Departamento de Bioquímica, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
4. Departamento de morfologia e fisiologia animal, Universidade Federal Rural de Pernambuco. Rua Dom Manoel de Medeiros, S/N, Dois Irmãos, Recife, PE, 52171-900 Pernambuco, Brasil.
5. Departamento de imunopatologia Keiso Asami (LIKA), Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
6. Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud, 150, Urca, RJ, 22290-180 Rio de Janeiro, Brasil.
7. Departamento de Farmácia, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.

Abstract

Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. It is known that substances capable of modulating the action of these oxidants on tissue may be important allies in the control of neovascularization in pathological processes. The aim of this study was to evaluate the antioxidant and antiangiogenic properties of an ethanol extract of Caesalpinia echinata. The evaluation of antioxidant properties was tested using two methods (DPPH inhibition and sequestration of nitric oxide). The antiangiogenic properties were evaluated using the inflammatory angiogenesis model in the corneas of rats. The extract of C. echinata demonstrated a high capacity to inhibit free radicals, with IC50 equal to 42.404 µg/mL for the DPPH test and 234.2 µg/mL for nitric oxide. Moreover, it showed itself capable of inhibiting the inflammatory angiogenic response by 77.49%. These data suggest that biochemical components belonging to the extract of C. echinata interfere in mechanisms that control the angiogenic process, mediated by substrates belonging to the arachidonic acid cascade, although the data described above also suggest that the NO buffer may contribute to some extent to the reduction in the angiogenic response.

Keywords: antioxidant, angiogenesis, Caesalpinia echinata, natural products

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
da Silva Gomes ECB, Jimenez GC, da Silva LCN, de Sá FB, de Souza KPC, Paiva GS, de Souza IA. Evaluation of Antioxidant and Antiangiogenic Properties of Caesalpinia Echinata Extracts. J Cancer 2014; 5(2):143-150. doi:10.7150/jca.7439. Available from http://www.jcancer.org/v05p0143.htm