J Cancer 2014; 5(2):86-97. doi:10.7150/jca.7963

Review

Emerging Biological Treatments for Uterine Cervical Carcinoma

Patrizia Vici1✉, Luciano Mariani2,3, Laura Pizzuti1, Domenico Sergi1, Luigi Di Lauro1, Enrico Vizza2, Federica Tomao4, Silverio Tomao5, Emanuela Mancini2, Cristina Vincenzoni2, Maddalena Barba1,6, Marcello Maugeri-Saccà1,6, Giuseppe Giovinazzo7, Aldo Venuti3,8

1. Department of Medical Oncology B, Regina Elena National Cancer Institute, V Elio Chianesi 53, 00144, Rome, Italy
2. Department of Gynecologic Oncology, Regina Elena National Cancer Institute, V Elio Chianesi 53, 00144, Rome, Italy
3. HPV Unit, Regina Elena National Cancer Institute, V Elio Chianesi 53, 00144, Rome, Italy
4. Department of Gynaecology and Obstetrics, “La Sapienza” University, V Policlinico 155, 00161, Rome, Italy
5. Department of Medical-Surgical Sciences and Biotechnologies, “La Sapienza” University of Rome, Oncology Unit, C.so della Repubblica, 04100, Latina, Italy
6. Scientific Direction, Regina Elena National Cancer Institute, V Elio Chianesi 53, 00144, Rome, Italy
7. Department of Radiation Oncology, Regina Elena National Cancer Institute,V Elio Chianesi 53, 00144, Rome, Italy
8. Laboratory of Virology, Regina Elena National Cancer Institute, V Elio Chianesi 53, 00144, Rome, Italy

Abstract

Cervical cancer is the third most common cancer worldwide, and the development of new diagnosis, prognostic, and treatment strategies is a major interest for public health. Cisplatin, in combination with external beam irradiation for locally advanced disease, or as monotherapy for recurrent/metastatic disease, has been the cornerstone of treatment for more than two decades. Other investigated cytotoxic therapies include paclitaxel, ifosfamide and topotecan, as single agents or in combination, revealing unsatisfactory results. In recent years, much effort has been made towards evaluating new drugs and developing innovative therapies to treat cervical cancer. Among the most investigated molecular targets are epidermal growth factor receptor and vascular endothelial growth factor (VEGF) signaling pathways, both playing a critical role in cervical cancer development. Studies with bevacizumab or VEGF receptor tyrosine kinase have given encouraging results in terms of clinical efficacy, without adding significant toxicity. A great number of other molecular agents targeting critical pathways in cervical malignant transformation are being evaluated in preclinical and clinical trials, reporting preliminary promising data.

In the current review, we discuss novel therapeutic strategies which are being investigated for the treatment of advanced cervical cancer.

Keywords: advanced cervical cancer, therapy, clinical trials, molecular targeted agents, tyrosine kinase inhibitors.

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How to cite this article:
Vici P, Mariani L, Pizzuti L, Sergi D, Di Lauro L, Vizza E, Tomao F, Tomao S, Mancini E, Vincenzoni C, Barba M, Maugeri-Saccà M, Giovinazzo G, Venuti A. Emerging Biological Treatments for Uterine Cervical Carcinoma. J Cancer 2014; 5(2):86-97. doi:10.7150/jca.7963. Available from http://www.jcancer.org/v05p0086.htm