J Cancer 2014; 5(1):58-68. doi:10.7150/jca.7047

Review

Current Approaches and Challenges in Monitoring Treatment Responses in Breast Cancer

Lindsey J. Graham1✉, Matthew P. Shupe1, Erika J. Schneble1, Frederick L. Flynt1, Michael N. Clemenshaw1, Aaron D. Kirkpatrick1, Chris Gallagher2, Aviram Nissan3, Leonard Henry4, Alexander Stojadinovic5, George E. Peoples1, Nathan M. Shumway1

1. San Antonio Military Medical Center (SAMMC), 3551 Roger Brooke Dr., Ft. Sam Houston, TX 78234, USA
2. Walter Reed National Military Medical Center (NMMC), 8901 Wisconsin Ave Bethesda, MD 20814, USA
3. Hadassah Medical Center, Kiryat Hadassah, POB 12000, Jerusalem, 91120, Israel
4. IU Health Goshen, 200 High Park Ave., Goshen, IN 46526, USA
5. Bon Secours Cancer Institute, 6505 West Broad St., Richmond, VA 23230, USA

Abstract

Monitoring response to treatment is a key element in the management of breast cancer that involves several different viewpoints from surgery, radiology, and medical oncology. In the adjuvant setting, appropriate surgical and pathological evaluation guides adjuvant treatment and follow up care focuses on detecting recurrent disease with the intention of improving long term survival. In the neoadjuvant setting, assessing response to chemotherapy prior to surgery to include evaluation for pathologic response can provide prognostic information to help guide follow up care. In the metastatic setting, for those undergoing treatment, it is crucial to determine responders versus non-responders in order to help guide treatment decisions. In this review, we present the current guidelines for monitoring treatment response in the adjuvant, neoadjuvant, and metastatic setting. In addition, we also discuss challenges that are faced in each setting.

Keywords: Breast cancer, Treatment monitoring, Future directions, Adjuvant, Neo-adjuvant, Metastatic

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How to cite this article:
Graham LJ, Shupe MP, Schneble EJ, Flynt FL, Clemenshaw MN, Kirkpatrick AD, Gallagher C, Nissan A, Henry L, Stojadinovic A, Peoples GE, Shumway NM. Current Approaches and Challenges in Monitoring Treatment Responses in Breast Cancer. J Cancer 2014; 5(1):58-68. doi:10.7150/jca.7047. Available from http://www.jcancer.org/v05p0058.htm