J Cancer 2014; 5(1):44-57. doi:10.7150/jca.7809

Review

Future Directions for Monitoring Treatment Response in Colorectal Cancer

Avery S. Walker1, Nathan P. Zwintscher1, Eric K. Johnson1, Justin A. Maykel2, Alexander Stojadinovic3, Aviram Nissan4, Itzhak Avital5, Björn LDM Brücher5, Scott R. Steele1✉

1. Department of Surgery, Madigan Army Medical Center, 9040 Fitzsimmons Dr., Fort Lewis, WA, USA
2. University of Massachusetts Memorial Medical Center, Worcester, MA, USA
3. Department of Surgery, Division of Surgical Oncology, Walter Reed National Military Medical Center, Bethesda, MD, USA
4. Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
5. Bon Secours Cancer Institute, Richmond, VA, USA

Abstract

Treatment of advanced colon and rectal cancer has significantly evolved with the introduction of neoadjuvant chemoradiation therapy so much that, along with more effective chemotherapy regimens, surgery has been considered unnecessary among some institutions for select patients. The tumor response to these treatments has also improved and ultimately has been shown to have a direct effect on prognosis. Yet, the best way to monitor that response, whether clinically, radiologically, or with laboratory findings, remains controversial. The authors' aim is to briefly review the options available and, more importantly, examine emerging and future options to assist in monitoring treatment response in cases of locally advanced rectal cancer and metastatic colon cancer.

Keywords: Colorectal cancer, response, biomarkers, watch and wait, imaging modalities, surgical timing

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How to cite this article:
Walker AS, Zwintscher NP, Johnson EK, Maykel JA, Stojadinovic A, Nissan A, Avital I, Brücher BL, Steele SR. Future Directions for Monitoring Treatment Response in Colorectal Cancer. J Cancer 2014; 5(1):44-57. doi:10.7150/jca.7809. Available from http://www.jcancer.org/v05p0044.htm