Online advance articles

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SCREENING STUDY ON THE ANTI-ANGIOGENIC EF-FECTS OF TRADITIONAL CHINESE MEDICINE – PART II: WILD CHRYSANTHEMUM
Xiang Tu, HeBin Wang, Qun Huang, Yi Cai, YuanPing Deng, Zhe Yong, Quan Hu, Jian Feng, James B. Jordan, Sen Zhong
J. Cancer 2020; doi:10.7150/jca.52971; in press
[Author manuscript]

Current Ovarian Cancer Maintenance Strategies and Promising New Developments
Vinaya Gogineni, Susan Morand, Hannah Staats, Rachel Royfman, Monika Devanaboyina, Katelyn Einoth, Danielle Dever, Laura Stanbery, Phylicia Aaron, Luisa Manning, Adam Walter, Gerald Edelman, Lance Dworkin, John Nemunaitis
J. Cancer 2020; doi:10.7150/jca.49406; in press
[Author manuscript]

The risk predicted dual Nomograms consisted of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions---A multiple center study
Zihan Niu, MM, Jia-Wei Tian, MD, Hai-Tao Ran, MD, Wei-Dong Ren, MD, Cai Chang, MD, Jian-Jun Yuan, MD, Chun-Song Kang, MD, You-Bin Deng, MD, Hui Wang, MD, Bao-Ming Luo, MD, Sheng-Lan Guo, MD, Qi Zhou, MD, En-Sheng Xue, MD, Wei-Wei Zhan, MD, Qing Zhou, MD, Jie Li, MD, Ping Zhou, MD, Chun-Quan Zhang, MD, Man Chen, MD, Ying Gu, MD, Jin-Feng Xu, MD, Wu Chen, MD, Yu-Hong Zhang, MD, Hong-Qiao Wang, MD, Jian-Chu Li, MD, Hong-Yan Wang, MD, Yu-Xin Jiang, MD
J. Cancer 2020; doi:10.7150/jca.51302; accepted
[Author manuscript]

Identifying Key Genes for Nasopharyngeal Carcinoma by Prioritized Consensus Differentially Expressed Genes Caused by Aberrant Methylation
Yunqin Chen, Chun Zhou, Huabin Li, Hong Li, Yixue Li
J. Cancer 2020; doi:10.7150/jca.49392; accepted
[Author manuscript]

The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
Xuewen Tan, Haifeng Jiang, Yilong Fang, Dafei Han, Wenming Hong, Jiajie Tu and Wei Wei
J. Cancer 2020; doi:10.7150/jca.49203; accepted
[Author manuscript]

Preoperative Denosumab May Increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis
Yongzhao Zhao, Zhenyu Cai, Xiaodong Tang, Zhiye Du, Yi Yang, Wei Guo
J. Cancer 2020; doi:10.7150/jca.50575; accepted
[Author manuscript]

The essential factors of establishing patient-derived tumor model
Chen chuanzhi
J. Cancer 2020; doi:10.7150/jca.51749; in press
[Author manuscript]

Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer
Min Li, Chi Chi, Liqin Zhou, Youguo Chen, Xiuwu Tang
J. Cancer 2020; doi:10.7150/jca.52234; accepted
[Author manuscript]

Minimal Residual Disease and Survival Outcomes in Patients with Mantle Cell Lymphoma: a systematic review and meta-analysis
Yu Zhou, Haizhu Chen, Yunxia Tao, Qiaofeng Zhong, Yuankai Shi
J. Cancer 2020; doi:10.7150/jca.51959; accepted
[Author manuscript]

Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor
Jianguo Lai, Jinjiang Lin, Hongli Wang, Yi Sun, Yudong Li, Huan Tian, Shiyu Shen, Cui Tan, Huanhuan Liu, Fengyan Yu
J. Cancer 2020; doi:10.7150/jca.49441; accepted
[Author manuscript]

HnRNP-F promotes the proliferation of bladder cancer cells mediated by PI3K/AKT/FOXO1
Fei Li, Weiwei Xie, Yunze Fang, Kunfeng Xie, Wendong Liu, Lina Hou, and Wanlong Tan
J. Cancer 2020; doi:10.7150/jca.50490; accepted
[Author manuscript]

MUC 15 Promotes Osteosarcoma Cell Proliferation, Migration and Invasion through Livin, MMP-2/MMP-9 and Wnt/β-Catnin Signal Pathway
Tonglei Chen, Zhenshi Chen, Xiaoning Lian, Weidong Wu, Lei Chu, Shaoru Zhang, Lihui Wang
J. Cancer 2020; doi:10.7150/jca.49641; accepted
[Author manuscript]

Synthesis and evaluation of 68Ga-labeled dimeric cNGR peptide for PET imaging of CD13 expression with ovarian cancer xenograft
Yi Yang; Jun Zhang; Huifeng Zou; Yang Shen; Shengming Deng; Yiwei Wu
J. Cancer 2020; doi:10.7150/jca.49628; accepted
[Author manuscript]

Long noncoding RNA DLEU2 affects the proliferative and invasive ability of colorectal cancer cells
Xiaoyun He, Bingbing Yu, Gaoyan Kuang, Yongrong Wu, Meili Zhang, Chunlin Ou
J. Cancer 2020; doi:10.7150/jca.48423; accepted
[Author manuscript]

The Inhibitory effects of recombinant Hespintor combined with Sorafenib on transplanted human hepatoma in nude mice, and transcriptional regulation of Hespintor based on RNA-Seq
Yong-Zhi Lun, Jie Sun, Ben Liu, Wen Dong, Ling-Hong Pan, Jian Lin, Jing-Xia Zhang
J. Cancer 2020; doi:10.7150/jca.50500; accepted
[Author manuscript]

Prognostic implication of glycolysis related gene signature in non-small cell lung cancer
Jie Yao, Rui Li, Xiao Liu, Xijia Zhou, Jianping Li, Tingting Liu, Chen Huo, Yiqing Qu
J. Cancer 2020; doi:10.7150/jca.50274; accepted
[Author manuscript]

A new method for the detection of colorectal cancer and the precancerous lesions: occult blood testing combination with promoter methylation in the fecal sample
Danyang Wang, Kangxin He, Ying Huang, Qinqin Lou, Ti He, Xiao Xu
J. Cancer 2020; doi:10.7150/jca.50525; accepted
[Author manuscript]

Targeting the CtBP1-FOXM1 transcriptional complex with small molecules to overcome MDR1-mediated chemoresistance in osteosarcoma cancer stem cells
Xun Chen, Qian Zhang, Xiaoqian Dang, Tao Song, Yufei Wang, Zirui Yu, Shihui Zhang, Jinzhu Fan, Fei Cong, Wentao Zhang, and Ning Duan
J. Cancer 2020; doi:10.7150/jca.50255; accepted
[Author manuscript]

Classification Of Clear Cell Renal Cell Carcinoma Based On Tumor Suppressor Genomic Profiling
Weimin Zhong, Fengling Zhang, Chaoqun Huang, Yao Lin, Jiyi Huang
J. Cancer 2020; doi:10.7150/jca.50462; accepted
[Author manuscript]

Lower dietary mineral intake is significantly associated with cervical intraepithelial neoplasia risk in a population-based case control study
Zhe Wang, Wenhao Wang, Aimin Yang, Weihong Zhao, Jing Yang, Zhilian Wang, Wei Wang, Xiaoqiang Su, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv, Dongyan Li, Huiqiang Liu, Chen Wang, and Min Hao
J. Cancer 2020; doi:10.7150/jca.39806; accepted
[Author manuscript]

Hypoxia Inducible Factor-1alpha (HIF-1A) May Play Different Roles in Gallbladder Cancer and Normal Gallbladder Tissues
Youliang Wu, Delong Meng, Yexiang You, Ruochuan Sun, Min Fu, Qiang Yan, Shangxin Zhang, Zheng Fang, Junjun Bao, Yongxiang Li
J. Cancer 2020; doi:10.7150/jca.46749; accepted
[Author manuscript]

Emerging Roles of MiR-133a in human cancers
Yu-Ting Hua, Wen-Xiu Xu, Hui Li, Min Xia
J. Cancer 2020; doi:10.7150/jca.48769; accepted
[Author manuscript]

Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells
Zhongyin Yang, Chao Yan, Zhenjia Yu, Changyu He, Jianfang Li, Chen Li, Min Yan, Bingya Liu, Yingli Wu, Zhenggang Zhu
J. Cancer 2020; doi:10.7150/jca.48193; accepted
[Author manuscript]

Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway
Chang Bao, Tao Liu, Lingbo Qian, Chi Xiao, Xinru Zhou, Heng Ai, Jue Wang, Weimin Fan and Jie Pan
J. Cancer 2020; doi:10.7150/jca.47553; in press
[Author manuscript]

The clinical and prognostic implication of deep stromal invasion in cervical cancer patients undergoing radical hysterectomy
Jun Zhu, Lijie Cao, Hao Wen, Rui Bi, Xiaohua Wu, Guihao Ke
J. Cancer 2020; doi:10.7150/jca.50752; in press
[Author manuscript]

Loss of LIMCH1 Predicts Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma: A Study Based on Immunohistochemical Analysis and Bioinformatics
He Cao, Jing Zhao, Zhen Chen, Wenjia Sun, Kexin Ruan, Jianya Zhou, Jianying Zhou
J. Cancer 2020; doi:10.7150/jca.47883; in press
[Author manuscript]

Gemcitabine, oxaliplatin and dexamethasone (GemDOx) as salvage therapy for relapsed or refractory diffuse large B-cell lymphoma and peripheral T-cell lymphoma
Qiu-Dan Shen, Li Wang, Hua-Yuan Zhu, Jin-Hua Liang, Yi Xia, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Wei Xu
J. Cancer 2020; doi:10.7150/jca.47031; in press
[Author manuscript]

Comparison of different lymph node staging systems in patients with node-positive cervical squamous cell carcinoma following radical surgery
Qinhao Guo, Jun Zhu, Yong Wu, Hao Wen, Lingfang Xia, Min Yu, Simin Wang, Xingzhu Ju, Xiaohua Wu
J. Cancer 2020; doi:10.7150/jca.48085; in press
[Author manuscript]

FLRT2 is Frequently Inactivated by Promoter Methylation in Colorectal Cancer and Functions as a Tumor Suppressor
Xiaohong Guo, Chao Song, Lei Fang, Min Li, Longtao Yue, Qing Sun
J. Cancer 2020; doi:10.7150/jca.47558; in press
[Author manuscript]

Distinct Reactive Oxygen Species Accumulation and Mitochondrion Oxidative Damage in Resveratrol Sensitive Glioblastoma Cells
Bin Jia, Xu Zheng, Xue Song, Xiao-Ting Tian, Yan-Na Liu, Mo-Li Wu, Pei-Nan Li, Jia Liu
J. Cancer 2020; doi:10.7150/jca.45489; in press
[Author manuscript]

Prognostic significance of the ratio of sodium to globulin in patients with advanced gastric cancer
Liqun Zhang, Zhuo Wang, Jiawen Xiao, Hao Chen, Zhiyan Zhang, Haijing Li, Yuanhe Wang, Haiyan Piao, Fang Li, Lisha Zhang, Jingdong Zhang
J. Cancer 2020; doi:10.7150/jca.47314; in press
[Author manuscript]

Characteristics and Differences of Gut Microbiota in Patients with Different Traditional Chinese Medicine Syndromes of Colorectal Cancer and Normal Population
Peipei Wang, Shuning Ding, Leitao Sun, Yuqian Feng, Kaibo Guo, Ying Zhu, Dawei Huang, Shanming Ruan
J. Cancer 2020; doi:10.7150/jca.50318; in press
[Author manuscript]

The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study
Mingyao Zhang, Zhiguang Zhao, Sailing Chen, Zongwen Liang, Jiawei Zhu, Manman Zhao, Chaoyi Xu, Jing He, Ping Duan, Anqi Zhang
J. Cancer 2020; doi:10.7150/jca.49925; in press
[Author manuscript]

Specific miRNAs in naïve T cells associated with hepatitis C virus-induced hepatocellular carcinoma
Peng Yan, Pengfei Pang, Xiaojun Hu, Ani Wang, Huitao Zhang, Yingdong Ma, Ke Zhang, Yaochao Ye, Bin Zhou, Junjie Mao
J. Cancer 2020; doi:10.7150/jca.49594; in press
[Author manuscript]

Amide-Type Local Anesthetics Suppress Tumor Growth and Sensitize the Cytotoxicity of Cisplatin in Human Hepatocellular Carcinoma Cells via Up-Regulation of RASSF1A Demethylation
Dongtai Chen, Yan Yan, Jingdun Xie, Jiahao Pan, Yonghua Chen, Qiang Li, Yunfei Yuan, Weian Zeng, and Wei Xing
J. Cancer 2020; doi:10.7150/jca.46630; in press
[Author manuscript]

Down-regulation of ACACA suppresses malignant progression of prostate cancer through inhibiting mitochondrial potential
Hui Zhang, Shaoyou Liu, Zhouda Cai, Weimin Dong, Jianheng Ye, Zhiduan Cai, Zhaodong Han, Yuxiang Liang, Yangjia Zhuo, Yong Luo, Xuejin Zhu, Yulin Deng, Yixun Zhang, Ren Liu, Yuanfa Feng, Jiarun Lai, Rui Zhou, Huijing Tan, Wei-de Zhong
J. Cancer 2020; doi:10.7150/jca.49560; in press
[Author manuscript]

Autophagy-mediated tumor cell survival and progression of breast cancer metastasis to the brain
APARNA MAITI AND NITAI HAIT
J. Cancer 2020; doi:10.7150/jca.50137; accepted
[Author manuscript]

Differential expression of epithelial sodium channels in human RCC associated with the prognosis and tumor stage: Evidence from Integrate Analysis
ShangFan Liao, Huaibin Huang, FaBiao Zhang, DongMing Lu, ShuChao Ye, LuoPing Zheng, Yingming Sun, YongYang Wu
J. Cancer 2020; doi:10.7150/jca.48970; in press
[Author manuscript]

GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway
Dianmin Sun, Yuanyuan Zong, Jinling Cheng, Zhenxiang Li, Ligang Xing, Jinming Yu
J. Cancer 2020; doi:10.7150/jca.46744; in press
[Author manuscript]

Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway
Lirong Chen, Chenhe Yi, Yujen Tseng, Jun Zhang, Jie Liu
J. Cancer 2020; doi:10.7150/jca.47526; accepted
[Author manuscript]

Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, LiLi Chen, Li Li
J. Cancer 2020; doi:10.7150/jca.50360; in press
[Author manuscript]

NKCC1 promotes proliferation, invasion and migration in human gastric cancer cells via activation of the MAPK-JNK/EMT signaling pathway
Jun-fu Wang, Kun Zhao, Ye-yang Chen, Yue Qiu, Jin-hui Zhu, Bo-pei Li, Zheng Wang and Jun-qiang Chen
J. Cancer 2020; doi:10.7150/jca.49709; in press
[Author manuscript]

Comprehensive investigation of the clinical significance of long non-coding RNA HOXA-AS2 in acute myeloid leukemia using genome-wide RNA sequencing dataset
Rui Huang, Xiwen Liao, Xiangkun Wang, Qiaochuan Li
J. Cancer 2020; doi:10.7150/jca.48045; accepted
[Author manuscript]

Comparison of Endoscopic Submucosal Dissection Application on Mucosal Tumor and Subepithelial Tumor in stomach
Wen-Hung Hsu, Tzung-Shiun Wu, Meng-Shu Hsieh, Yu-Min Kung, Yao-Kuang Wang, Jeng-Yih Wu, Fang-Jung Yu, Chao-Hung Kuo, Yu-Chung Su, Jaw-Yuan Wang, Deng-Chyang Wu, Huang-Ming Hu
J. Cancer 2020; doi:10.7150/jca.47653; accepted
[Author manuscript]

Regulation and biological functions of CX3CL1-CX3CR1 axis and its relevance in cancer
Selma Rivas-Fuentes, Alfonso Salgado-Aguayo, Jenny Arratia-Quijada and Patricia Gorocica-Rosete
J. Cancer 2020; doi:10.7150/jca.47022; accepted
[Author manuscript]

LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma
Longrong Wang, Kai Yan, Xigan He, Hongxu Zhu, Jia Song, Shiqing Chen, Shangli Cai, Yiming Zhao, Lu Wang
J. Cancer 2020; doi:10.7150/jca.48983; accepted
[Author manuscript]

Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications
Shunyao Zhu, Ziyi Luo, Xixi Li, Xi Han, Senlin Shi, Ting Zhang
J. Cancer 2020; doi:10.7150/jca.49692; accepted
[Author manuscript]

Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer
Caoli Tang, Duanya Liu, Yongsheng Fan, Jun Yu, Cong Li, Jianmei Su and Chunhong Wang
J. Cancer 2020; doi:10.7150/jca.47158; accepted
[Author manuscript]

Current Progress in CAR-T Cell Therapy for Hematological Malignancies
Donglei Han, Zenghui Xu, Yuan Zhuang, Zhenlong Ye, Qijun Qian
J. Cancer 2020; doi:10.7150/jca.48976; accepted
[Author manuscript]

EVALUATION OF ANTI-CANCER FUNCTION OF TRANSGENIC HEMATOPOIETIC NATURAL KILLER CELLS
Alireza Pirahmadiana, Shaharudin Abdul Razak, Shamsul Azlin B Ahmad Shamsuddin
J. Cancer 2020; doi:10.7150/jca.48343; accepted
[Author manuscript]

Demethylzelasteral Contributes to Epithelial-Mesenchymal Transition (EMT) in ESCC through the Wnt/β-catenin Signaling Pathway
Jiarui Yu, Wei Wang, Baolin Liu, Jinling Gu, Meiyue Liu, Siyuan Chen, Guogui Sun
J. Cancer 2020; doi:10.7150/jca.45493; accepted
[Author manuscript]

Genomic variants in Fas-mediated apoptosis pathway predict a poor response to platinum-based chemotherapy for Chinese gastric cancer patients
Tingting Zhao, Wei Li, Xiaodong Xu, Weisong Qin, Jinfei chen
J. Cancer 2020; doi:10.7150/jca.48120; accepted
[Author manuscript]

Multimodality MRI-based Prediction Model for Histologic Grade of Hepatocellular Carcinoma
Baolin Wu, Fei Jia, Xuekun Li, Kaiyu Wang, Dongming Han, Zhiyun Jia
J. Cancer 2020; doi:10.7150/jca.49029; accepted
[Author manuscript]

ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3
Qian Chen, Wen-juan Fu, Xiao-peng Tang, Lu WangQin Niu, Shuai WangYong Lin, Mian-fu Cao, Rong Hu, Hai-Yan Wen Yan Wang, Xia Zhang and Xiao-hong Yao
J. Cancer 2020; doi:10.7150/jca.45052; accepted
[Author manuscript]

USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer
Dao-xiong Ye, MD; Si-si Wang, MM; Ying Huang, MD; Xiao-jie Wang, MD; Pan Chi, MD
J. Cancer 2020; doi:10.7150/jca.48056; accepted
[Author manuscript]

U three protein 14a (UTP14a) promotes tumor proliferation and metastasis via PERK/ eIF2a/ GRP78 signaling pathway in esophageal squamous cell carcinoma
Kun-Kun Li, Cheng-Yi Mao, Qiang Ma, Tao Bao, Ying-Jian Wang, Wei Guo, Xiao-Long Zhao
J. Cancer 2020; doi:10.7150/jca.44649; in press
[Author manuscript]

18F-FDG PET/CT Scans Can Identify Sub-Groups of NSCLC Patients with High Glucose Uptake in the Majority of Their Tumor Lesions
Anne M. Hendriks, Adrienne H. Brouwers, Panagiotis Giannopoulos, Joop D. Lefrandt, Wim Timens, Harry J.M. Groen, Geertruida H. de Bock, Mathilde Jalving
J. Cancer 2020; doi:10.7150/jca.45899; accepted
[Author manuscript]

New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study
Haimiao Chen, Ting Wang, Shuiping Huang, Ping Zeng
J. Cancer 2020; doi:10.7150/jca.47918; accepted
[Author manuscript]

ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathway
Shasha Chen, Bin Wang, Xuekun Fu, Yanfang Liang, Xingxing Chai, Ziyu Ye, Ronggang Li, Yaoming He, Gang Kong, Mingyuan Huang, Xiangyong Li, Caihong Li, Xin Zhang, Xianxiu Qiu, Xudong Tang, Keyuan Zhou, Bihua Lin, Jincheng Zeng
J. Cancer 2020; doi:10.7150/jca.46447; in press
[Author manuscript]

Genomic profiling of blood-derived circulating tumor DNA from patients with advanced biliary tract cancer
Junying Wang, Jia Song, Mengmei Yang, Jing Zhao, Shangli Cai, Yuezong Bai, Chen Chen
J. Cancer 2020; doi:10.7150/jca.45572; accepted
[Author manuscript]

A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC
Divya Wahi, Deepika Soni, Abhinav Grover
J. Cancer 2020; doi:10.7150/jca.41160; accepted
[Author manuscript]

The association between sites of distant metastases and overall survival in cervical cancer
Ce Wang, Zhenyi Xu, Jiali Song, Yuhong Lu, Meng Wang, Yan Hou
J. Cancer 2020; doi:10.7150/jca.41046; accepted
[Author manuscript]


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