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J Cancer 2018; 9(3):548-555. doi:10.7150/jca.22968 This issue Cite

Research Paper

Clinical study on the prevalence and comparative analysis of metabolic syndrome and its components among Chinese breast cancer women and control population

Yu-tuan Wu^1*, Qing-qing Luo^1*, Xin Li^1*, Bilal Arshad^1*, Zhou Xu^1*, Liang Ran², Chun-xia Zhao¹, He Wu¹, Yan-ling Shi¹, Hao-ran Chen¹, Hao Li¹, Hong-yuan Li¹, Kai-nan Wu¹, Ling-quan Kong^1✉

1. Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;
2. Department of Physical Examination, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
* These authors contributed equally to this work.

✉ Corresponding author: Ling-quan Kong, e-mail: huihuikpcom, Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, No.1 You Yi Rd., Chongqing 400016, China.

Abstract

Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its components in the breast cancer (605 cases) and control population (3212 cases), from Breast Cancer Center and Physical Examination Center of Chongqing, China, from July 2015 to February 2017, were collected for comparative analysis. This study was prospectively registered in Chinese Clinical Trial Registry (http://www.chictr.org.cn/, number: ChiCTR-OOB-15007543). The prevalence of metabolic syndrome in breast cancer (32.6%) was obviously higher than that in control population (18.2%) (p<0.001; OR: 2.173, 95%CI: 1.793 to 2.633). With age stratification, the prevalence of metabolic syndrome in breast cancer group aged below 60 years (24.9%, p<0.001; OR: 2.216, 95%CI: 1.744 to 2.816) and equal/above 60 years (58.3%, p<0.001; OR: 2.291, 95%CI: 1.580 to 3.322) were also statistically higher than those (13.0% & 37.9%) in control population, respectively. Breast cancer women were more likely to have preobese (BMI 25.0-29.9) or obesity (BMI ≥30.0), broader waist circumference, lower HDL-C level, higher systolic and/or diastolic blood pressure and higher fasting blood glucose level compared to the control population, corresponding prevalence were 31.7%vs.19.4%, 76.0%vs.29.6%, 37.4%vs.30.4%, 34.2%/27.3%vs.27.6%/14.2% and 25.0%vs.20.1%, respectively (p<0.01). In summary, there is high prevalence of metabolic syndrome and its components in Chinese breast cancer women, and metabolic syndrome is closely related with breast cancer. Therefore, screening and prevention strategy of metabolic syndrome should be carried out in the management of breast cancer.

Keywords: Breast cancer, metabolic syndrome, dyslipidemia, hypertension, hyperglycemia.

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