J Cancer 2018; 9(3):479-487. doi:10.7150/jca.22157

Research Paper

Clinicopathological Characteristics of the primary and metastatic Hepatic Neuroendocrine Tumors and the relevant Prognosis-Related Factors: A Retrospective Study of 81 Cases in a Single Chinese Center

Yang Lv1*, Cheng Huang2*, Haizhou Xu3*, Xu Han1, Lei Zhang1, Weilin Mao1, Yuan Ji4, Dayong Jin1, Wenhui Lou1✉, Xuefeng Xu1✉

1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China;
2. Department of Hepatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China;
3. Department of General Surgery, Nantong Second People's Hospital, Nantong, Jiangsu, China;
4. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
* Equal contributors.

Abstract

Aims: We aim to describe the clinicopathological characteristics of hepatic neuroendocrine tumors (HNETs) and evaluate the relevant prognosis-related factors.

Methods: The clinical data of 81 consecutive patients with primary or metastatic HNETs from March 2000 to July 2014 were retrospectively analyzed.

Results: The mean (SD) age was 59.68 (11.64) years, 69.15% were men. The percentages of Grade G1, G2 and G3 tumors were 4.94%, 25.93% and 69.13%, respectively. Thirty-five cases were primary HNETs. Primary HNETs were more common in patients with larger tumors, lymph nodes invasions, tumor necrosis and portal vein tumor thrombus. The 1-, 3-, and 5-year overall survival rate were 88.89%, 32.10%, and 8.64%, separately. The relapse rate was 81.48% (66/81) and the mean (SD) relapse time was 18.79 (10.99) months. Reduced survival rate was associated with lymph node metastases (P=0.034), tumor necrosis (P=0.048), hard texture of tumor character (P=0.001), multifocality of tumor numbers (P=0.043), and the immunohistochemical expression of NSE (P=0.000) and Syn (P=0.037). Patients with metastatic HNETs were demonstrated with a more decreased period of Progression-free Survival (PFS) and Overall survival (OS) than their primary HNETs counterparts (P<0.05).

Conclusion: Primary HNETs cohort patients were more common with aggressive clinical presentation. The hard texture of tumor character, multifocality of tumor numbers, and the immunohistochemical expression of NSE and Syn were independent predictive factors. Patients who were pathologically diagnosed as the primary HNETs seemed to achieve a long-term survival.

Keywords: hepatic neuroendocrine tumors, clinicopathological characteristics, prognosis.

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How to cite this article:
Lv Y, Huang C, Xu H, Han X, Zhang L, Mao W, Ji Y, Jin D, Lou W, Xu X. Clinicopathological Characteristics of the primary and metastatic Hepatic Neuroendocrine Tumors and the relevant Prognosis-Related Factors: A Retrospective Study of 81 Cases in a Single Chinese Center. J Cancer 2018; 9(3):479-487. doi:10.7150/jca.22157. Available from http://www.jcancer.org/v09p0479.htm