J Cancer 2017; 8(13):2436-2441. doi:10.7150/jca.19421 This issue Cite

Research Paper

HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China

Baowen Zheng1*, Huaitao Yang2*, Zaibo Li 3, Guijian Wei1, Jia You1, Xiaoman Liang1, Chengquan Zhao4✉

1. Guangzhou Kingmed Diagnostics, Guangzhou, Guangdong 510330, P. R. China;
2. Department of Pathology, University Cincinnati College of Medicine, Cincinnati, OH 45219, USA;
3. Department of Pathology, Wexner Medical Center at Ohio State University, Columbus, OH 43210, USA;
4. Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
* Both authors made equal contributions to this paper.

Citation:
Zheng B, Yang H, Li Z, Wei G, You J, Liang X, Zhao C. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J Cancer 2017; 8(13):2436-2441. doi:10.7150/jca.19421. https://www.jcancer.org/v08p2436.htm
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Abstract

Background: Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory.

Methods: Patients with LSIL between 2011 and 2015 from the Guangzhou Kingmed Diagnostics were retrospectively retrieved and their hrHPV test results and histological follow-up results were collected and analyzed.

Results: LSIL result was identified in 37,895 cases from 2,206,588 Pap tests (1.7%) including 1,513,265 liquid-based cytology and 693,323 conventional Pap tests. The average of these women was 38.4 years (15-88). The LSIL reporting rate in women <30 years was significantly higher than that in women > 30 years (2.1% vs 1.7%). The age specific reporting LSIL rates declined with increased age. 8,014 of 37,895 (21.2%) women with LSIL cytology also had HC2 HPV test results. 75.8% of women with LSIL Pap tests were hrHPV+ and the HPV+ rates declined with increased age except in patients older than 60 years. Overall histopathologic diagnoses within 6 months after LSIL were identified in 5,987 of 37,895 patients at Guangzhou Kingmed Diagnostics. CIN2/3 was identified in 15.2% patients, CIN1 in 66.9%, negative in 14.9% patients. No invasive carcinoma was found in all patients. Of 8014 patients with LSIL Pap test and HPV testing results, 1727 patients had histological follow-up within 6 months after Pap cytology test and HPV testing. The detection rate of CIN2/3 was significantly higher in patients with positive HPV testing result than that in patients with negative HPV testing result (17.8% vs. 8.1%). Among patients with LSIL/HPV negative tests, CIN2/3 was detected in 1 of 30 (3.3%) women aged 50 years and above, appearing lower than those in women less than 50 years (8.0%, 28/351, P=0.357).

Conclusion: This is the largest histological follow-up study in women with LSIL Pap from China and the data are helpful in establishing a baseline for better understanding the status of cervical screening in China. The 85.1% positive predict value of LSIL Pap cytology for follow-up CIN lesion was within currently recognized benchmark ranges.

Keywords: cervical cytology, LSIL, HPV, CIN, Cervical cancer, China.


Citation styles

APA
Zheng, B., Yang, H., Li, Z., Wei, G., You, J., Liang, X., Zhao, C. (2017). HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. Journal of Cancer, 8(13), 2436-2441. https://doi.org/10.7150/jca.19421.

ACS
Zheng, B.; Yang, H.; Li, Z.; Wei, G.; You, J.; Liang, X.; Zhao, C. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J. Cancer 2017, 8 (13), 2436-2441. DOI: 10.7150/jca.19421.

NLM
Zheng B, Yang H, Li Z, Wei G, You J, Liang X, Zhao C. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J Cancer 2017; 8(13):2436-2441. doi:10.7150/jca.19421. https://www.jcancer.org/v08p2436.htm

CSE
Zheng B, Yang H, Li Z, Wei G, You J, Liang X, Zhao C. 2017. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J Cancer. 8(13):2436-2441.

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