J Cancer 2016; 7(15):2341-2345. doi:10.7150/jca.16947

Short Research Communication

Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells

Mindy Muñoz1, Madeleine Craske2, Patricia Severino3, Thais Martins de Lima4, Paul Labhart2, Roger Chammas5, Irineu Tadeu Velasco4, Marcel Cerqueira César Machado4, Brian Egan2, Helder I Nakaya1, Fabiano Pinheiro da Silva4✉

1. Departamento de Análises Clínicas e Toxicológicas, Instituto de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.
2. Active Motif Incorporation, Carlsbad, California, USA.
3. Instituto Israelita de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, Brazil.
4. Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
5. Departamento de Oncologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Abstract

Antimicrobial peptides are an ancient family of molecules that emerged millions of years ago and have been strongly conserved during the evolutionary process of living organisms. Recently, our group described that the human antimicrobial peptide LL-37 migrates to the nucleus, raising the possibility that LL-37 could directly modulate transcription under certain conditions. Here, we showed evidence that LL-37 binds to gene promoter regions, and LL-37 gene silencing changed the transcriptional program of melanoma A375 cells genes associated with histone, metabolism, cellular stress, ubiquitination and mitochondria.

Keywords: LL-37, transcription factors, antimicrobial peptides, cancer.

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How to cite this article:
Muñoz M, Craske M, Severino P, de Lima TM, Labhart P, Chammas R, Velasco IT, Machado MCC, Egan B, Nakaya HI, Pinheiro da Silva F. Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells. J Cancer 2016; 7(15):2341-2345. doi:10.7150/jca.16947. Available from http://www.jcancer.org/v07p2341.htm