J Cancer 2016; 7(9):1174-1180. doi:10.7150/jca.15243

Research Paper

Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience

Yoon Jung Oh1*, Seong Yoon Yi2*, Ki Hyang Kim3, Yong Jin Cho4, Seung Hoon Beum5, Young Han Lee6, Jin-Suck Suh6, Hyuk Hur7, Kyung Sik Kim7, Sung Hoon Kim8, Young Deuk Choi9, Kyoo-Ho Shin4, Hyun Jung Jun10, Sung Joo Kim11, Jeeyun Lee12, Se Hoon Park12, Sung Hoon Noh7, Sun Young Rha5, Hyo Song Kim5✉

1. Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea;
2. Division of Hematology-Oncology, Department of Internal Medicine, Inje University Ilsan Paik Hospital; Ilsan, Korea;
3. Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea;
4. Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea;
5. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
6. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea;
7. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea;
8. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea;
9. Department of Urology, Yonsei University College of Medicine, Seoul, Korea;
10. Division of Medical Oncology & Hematology, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea;
11. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;
12. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
*Yoon Jung Oh and Seong Yoon Yi equally contributed to this work as first authors.

Abstract

Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma.

Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study.

Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors.

Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.

Keywords: Liposarcoma, Asian, Prognostic model, Survival.

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How to cite this article:
Oh YJ, Yi SY, Kim KH, Cho YJ, Beum SH, Lee YH, Suh JS, Hur H, Kim KS, Kim SH, Choi YD, Shin KH, Jun HJ, Kim SJ, Lee J, Park SH, Noh SH, Rha SY, Kim HS. Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience. J Cancer 2016; 7(9):1174-1180. doi:10.7150/jca.15243. Available from http://www.jcancer.org/v07p1174.htm