J Cancer 2015; 6(12):1206-1213. doi:10.7150/jca.12535 This issue Cite

Review

May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?

Xiaoling Wu1, 2, Xiaohui Tan2, Sidney W. Fu2✉

1. Department of Gastroenterology, Chengdu Military General Hospital, Chengdu, China
2. Department of Medicine (Division of Genomic Medicine), The George Washington University School of Medicine and Health Sciences, Washington, DC

Citation:
Wu X, Tan X, Fu SW. May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?. J Cancer 2015; 6(12):1206-1213. doi:10.7150/jca.12535. https://www.jcancer.org/v06p1206.htm
Other styles

File import instruction

Abstract

Gastric cancer (GC) is the third leading cause of cancer-related deaths. More than 80% of the diagnosis was made at the advanced stages of the disease, highlighting the urgent demand for novel biomarkers that can be used for early detection. Recently, a number of studies suggest that circulating microRNAs (miRNAs) could be potential biomarkers for GC diagnosis. Cancer-related circulating miRNAs, as well as tissue miRNAs, provide a hopeful prospect of detecting GC at early stages, and the prospective participation of miRNAs in biomarker development will enhance the sensitivity and specificity of diagnostic tests for GC. As miRNAs in blood are stable, their potential value as diagnostic biomarkers in GC has been explored over the past few years. However, due to the inconsistent or sometimes conflicting reports, large-scale prospective studies are needed to validate their potential applicability in GC diagnosis. This review summarizes the current development about potential miRNA biomarkers for GC diagnosis and the obstacles hindering their clinical usage.

Keywords: gastric cancer, circulating miRNA, diagnosis, biomarkers


Citation styles

APA
Wu, X., Tan, X., Fu, S.W. (2015). May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?. Journal of Cancer, 6(12), 1206-1213. https://doi.org/10.7150/jca.12535.

ACS
Wu, X.; Tan, X.; Fu, S.W. May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?. J. Cancer 2015, 6 (12), 1206-1213. DOI: 10.7150/jca.12535.

NLM
Wu X, Tan X, Fu SW. May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?. J Cancer 2015; 6(12):1206-1213. doi:10.7150/jca.12535. https://www.jcancer.org/v06p1206.htm

CSE
Wu X, Tan X, Fu SW. 2015. May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?. J Cancer. 6(12):1206-1213.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image