J Cancer 2014; 5(9):765-773. doi:10.7150/jca.10471
Interleukin-7 and Interleukin-15 for Cancer
1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
2. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, U.S.A.
3. Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
4. II Medical Clinic, ``Coburg`` Hospital, University of Wuerzburg, Coburg, Germany.
5. Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, China.
6. Pathology Department, ``G. Papanikolaou`` General Hospital, Thessaloniki, Greece.
7. Oncology Department, ``BioMedicine`` Private Hospital, Thessaloniki, Greece.
8. Cardiothoracic Surgery Department, ``Saint Luke`` Private Hospital, Thessaloniki, Greece.
9. Oncology Department, ``G. Papageorgiou`` University Hospital, Thessaloniki, Greece.
10. Oncology Department, ``Sotiria`` Hospital, University of Athens, Athens, Greece.
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.
Keywords: IL-7, IL-15, Cancer, Imunomodulation.
Zarogoulidis P, Lampaki S, Yarmus L, Kioumis I, Pitsiou G, Katsikogiannis N, Hohenforst-Schmidt W, Li Q, Huang H, Sakkas A, Organtzis J, Sakkas L, Mpoukovinas I, Tsakiridis K, Lazaridis G, Syrigos K, Zarogoulidis K. Interleukin-7 and Interleukin-15 for Cancer. J Cancer 2014; 5(9):765-773. doi:10.7150/jca.10471. Available from http://www.jcancer.org/v05p0765.htm