J Cancer
2013; 4(4):320-322.
doi:10.7150/jca.3619 This issueCite
Short Research Communication
Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature
Ibrahim Halil Sahin, Syed M.A. Kazmi, Jeffrey T. Yorio, Nishin A. Bhadkamkar, Bryan K. Kee, Christopher R. Garrett✉
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, Texas, 77030-4009.
✉ Corresponding author: Christopher Garrett, MD, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, Texas, 77030-4009. Email: cgarrettorg Tel: 713-792-2828 Fax: 713-792-4032.More
Citation:
Sahin IH, Kazmi SMA, Yorio JT, Bhadkamkar NA, Kee BK, Garrett CR. Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature. J Cancer 2013; 4(4):320-322. doi:10.7150/jca.3619. https://www.jcancer.org/v04p0320.htm
KRAS mutations occur frequently in colorectal cancers (CRC) and predict lack of response to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy. CRC BRAF mutations, most commonly at V600E, occur less than 10% of the time, and occur usually in KRAS wild-type tumors, and more frequently in microsatellite instable tumors. Concomitant KRAS and BRAF mutant CRCs are rare (occurring in 0.001%); BRAF mutations should not be routinely tested in patients with KRAS mutant tumors, unless the patients is participating in a clinical trial enriching for the presence of a KRAS or BRAF tumor. Clinical trials treating patients with either KRAS or BRAF mutant tumors should address eligibility of patients with concomitant KRAS and BRAF mutations.
Keywords: Concomitant KRAS, BRAF
Citation styles
APA
Sahin, I.H., Kazmi, S.M.A., Yorio, J.T., Bhadkamkar, N.A., Kee, B.K., Garrett, C.R. (2013). Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature. Journal of Cancer, 4(4), 320-322. https://doi.org/10.7150/jca.3619.
ACS
Sahin, I.H.; Kazmi, S.M.A.; Yorio, J.T.; Bhadkamkar, N.A.; Kee, B.K.; Garrett, C.R. Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature. J. Cancer 2013, 4 (4), 320-322. DOI: 10.7150/jca.3619.
NLM
Sahin IH, Kazmi SMA, Yorio JT, Bhadkamkar NA, Kee BK, Garrett CR. Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature. J Cancer 2013; 4(4):320-322. doi:10.7150/jca.3619. https://www.jcancer.org/v04p0320.htm
CSE
Sahin IH, Kazmi SMA, Yorio JT, Bhadkamkar NA, Kee BK, Garrett CR. 2013. Rare Though Not Mutually Exclusive: A Report of Three Cases of Concomitant KRAS and BRAF Mutation and a Review of the Literature. J Cancer. 4(4):320-322.